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Adenosine A1 receptor activator T62

CAS No. 40312-34-3

Adenosine A1 receptor activator T62( —— )

Catalog No. M26600 CAS No. 40312-34-3

Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[2][3].

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Adenosine A1 receptor activator T62
  • Note
    Research use only, not for human use.
  • Brief Description
    Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[2][3].
  • Description
    Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[2][3].(In Vivo):Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect. However it has no effect on ambulation or activity level.
  • In Vitro
    ——
  • In Vivo
    Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. Animal Model:Male SpragueDawley rats (250 g) after paw incision surgery Dosage:0.3 μg, 0.5 μg, 1 μg, and 3 μg Administration:Intrathecal administration Result:Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    PDE4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40312-34-3
  • Formula Weight
    291.79
  • Molecular Formula
    C15H14ClNOS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1sc2CCCCc2c1C(=O)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Manuel Mata, et al. Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation. Free Radic Res. 2012 May;46(5):690-9.
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